For Dune and Dune 2 i both get

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C:\dune2\dune2.exe

C:\WINDOWS\SYSTEM32\AUTOEXE.NT. The system file is not sutible for running MS-DOS and Microsoft Windows appltcations. Chose 'close' to terminate the application.
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C:\dune2\dune2.exe is the folder i un-ziped it into and i try to run the game out of.

This is probably my system so plz give me some advice.

PS Maniac Masion works fine on my computer!

Pinned here since a long while now.