I only happened to fight the Overspawn once, but, like some others said, that was before I decided my ships needed a whole change of tactics and armament. If you see the mothership (or battleship, I'm not sure which ones drop it), let it be until it deploys the Overspawn. I think you need an entire alien containment facility to keep it's cadaver after you kill it.
I can say that the Overspawn is the only reason I used the Griffon Tank.
...Don't you need to do the autopsy on the Overspawn to unlock something, though?
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