A good indication is the number of days you can do with a full load of food & water + of course the speed your ship reaches under optimal and worst conditions. I'd always try for a range of 40 days or more, and take a relatively light ship to reach a decent speed. Still it needs to be tough so it survives long trips.
Like Laiocfar said, have a minimum crew + say 10% extra: sometimes random events take out part of your crew, and you don't want to be stuck at a speed of 2-6 knots because you lost 5 crew members...
Final note: stock balm, preferably 10-15 of your 20 items. Have a cat around, and optionally also lime juice.
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A sickened, sensitive shadow writhing in hands that are not hands, and whirled blindly past ghastly midnights of rotting creation (Nyarlathotep, H.P. Lovecraft)
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