Fun game, funner now that I know how to decrease numbers.
Anyways, you have to think historically to make a profit. It sort of means you have to know a little about this era in order to survive, a few big time routes I know off hand are:
Tea from India to London
Cotton from Savannah or Port Said to London
Both are historical; Tea was a major item for the British, and Cotton was in it's "booming period" and will remain so until 1865. After that the price drops.
You can also smuggle arms, as someone mentioned. It's very lucrative, and there are three times in this game where wars break out, allowing you to smuggle arms.
Crimean War - Ship arms to Odessa
Opium War - Ship arms to Macao
Civil War - Ship arms to Savannah or New Orelans (Not so sure on this one)
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