Genoa does sell silver, it's its specialty, and I use it to manipulate both Genoa's and Madeira's market to 150% and 50%, respectively. Madeira-Genoa is still more profitable than any other route, mainly because it's way shorter and therefore quicker to complete than the rest. I can make two million pieces of gold per trip with just two Venetian Galeasses, so technically I could make 10 million with 10 of those ships.
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