I think that your problem, which was common with old games --but never appears if you use DOSBox-- is about low memory. That's the fisrt 640 kb, the fastest and only directly compatible portion of RAM.
TSR stands for "Terminate and Stay Resident", it means the DOS programs which resided in memory, something slightly similar to the programs you see in Windows's Task Manager when you press Ctrl+Alt+Del. They occupy memory, and many of them needed low memory. So under DOS you could modify some lines from CONFIG.SYS and AUTOEXEC.BAT in order to try and load them in high memory, or remove them if they were not neccesary.
About the edition... Copy-post the content of the boxes here and I'll see if I can help you.
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