I'm up to the last level with Harkonnen and I've never run out of spice. Most levels however I've been able to reach the 33000 spice cap at the end of the level and racked up some huge scores when I finally decide to blow the last building. Mind you, that may be because Harkonnen are easy.
I think however it is important to also monitor what your harvestors are doing when you hit the unit limit. There isn't always time to keep building silos and a lot of spice can be lost if you are attacking, not paying attention and your harvestors are just dumping the spice as there is no space. Several times I have chosen to sit on about 5000 spice while attacking and have ordered my harvestors to stop working.
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