If you don't play the game in DosBox, but in Windows XP or 98, I would say the crashes happen because of too fast memory OR just because the computer is too fast - if the second is true you have two options:
1. Play the game in DosBox - shouldn't crash there
2. Use a slowdown program together with the game, I would recommend SlowDown, you can get it here for free:
http://newton.pbk-solutions.de/ncu_nbu/slowdown.htm
About the mouse, I think there's the same solution about it (you did mean it is too fast didn't you?) - SlowDown.