It is the first time I ever suggest this, but it is worth a try:
Try opening TTDX Configurator.exe. If it works, load TTD .cfg file and make sure the last option bottom right, "use Windows 2000/xp Compatibility settings" is checked.
If it still don't work, or it is already checked... Try selecting the option right above, "rebuild ttdpatch.ovl on every run".
It seems like setup.bat also try to enter something in the registery. You could also try that.
Edit: also, make sure you don't have an anti-spyware or any kind of spyware which prevent other programs to write in the registory. Norton Antivirus could possibly fall in that category too, depending of your version... If you use it.
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