A lot of these problems (the operation not working, the drill not stopping) are fixed by setting Dosbox's cycles lower, until the in-game time is the same as real-time (1 second = 1 second and not 1 irl = 10 ingame).
If you don't do this - you can't do everything fast enough and so can't complete the trickier operations.
As soon as you notice an emergency problem, if it's not fixed, you lose. That can be really annoying if you have a load of bleeders to look after or have to irrigate constantly.
The drill and other things, like the scalpel (big problem

) get stuck at too high cycles, too. That's even more annoying - especially when doing something intricate.
I hate to plug this again, but have you followed all the steps in this guide?
http://trgt.googlegroups.com/web/LAD...uide.pdf?hl=en
idk if it's ever going on site,
but I need to add the cycles thing to the pdf guide.
I was pretty much set to beat my record of 10:39 for an aneyrism. I got to the bit (right at the end of the hard bit) where you have to take off the retractors and the brain closes back up and you do - what should be the NURSE'S job, I may add - the closing the scalp back up bit...
...AND THE FREAKING MOUSE STUCK AND I SCALPELED THE GUY'S BRAIN!!!
They ate pizza off his body.
I went and chatted with the psychologist computer about my failure as a brain surgeon being due to faulty equipment.
He kept asking me the same annoying questions, though.
Could've made less than 10 minutes, easy...