I would say you've already got the best software. I use AVG and Zone Alarm and they've never affected my system performance at all. I would guess your problem is with something else, not your antivirus and firewall.
EDIT: I use spybot s&d for spyware but I don't think there's a great deal to choose between anti-spyware software. My computer goes through periods of running really slow and it nearly always turns out to be adware or spyware that has slipped through the defences!
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