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[Grand Dad]

Well I always prefer starting in the Amazon area, preferably near a hill, then expanding north and westwards. South is scrub and very unproductive. Dislike the islands - too little space and fewer raw material plus places like Cuba have the Arawaks who are very unreliable. The Tupis can easily be subdued.
Never sell horses, guns or tools to them unless you aim to arm them against the other Europeans. And I never attack a village unless they force me to.
It's always better to send a missionary to a capital. The Incas are usually very co-operative.

happy Gaming!