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Basically what the fatal error when I play TTDX is is that it complains about something to do with language. I believe the error is something like this:

Error: "1033" is a bs language which was defined in some environment variable. You can choose from English, Spanish, etc with lang=english and such.

My System Specs:
Windows XP Home Edition
Intel Celeron 2.2gHz
40GB Hard Drive
256MB DDR RAM
3D Intel Extreme Graphics AGP

I hope that helps.