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[Saccade]

I've never had problems on PC or Mac, on all versions of Dosbox and Boxer I have ever used, except for tweaking teh cycles.
Maybe run it in windowed mode instead, but decrease Window's display resolution so it's still big enough to play.

Wait - sometimes the mouse sticks and you drill into brain or skid it across the bone (and they let them die and HUMILIATE their corpses, just because you put a tiny ding - that they'd never even know was there if you didn't tell them - in their cranium?! Their head's gonna be sore anyway!).
That could be because of the dramatically reduced cycles, tho.

Use WinXP and latest Dosbox.
Vista sucks and Win7 scares me.