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[dkw]

Dungeon Master, cloned beyond belief, created the First Person RPG interface, looks about 4 years ahead of its time in graphics, and set the standard for future first person games and RPGs.
Some of the known Clones
Eye of the Beholder Trilogy
Lands of Lore
Might and Magic 3 and beyond
Anvil of Dawn

Civilization, created the standard for Empire building, globe spanning, turn based games. Series still going strong today.

X-COM UFO Defense (aka UFO Enemy Unknown), a sleeper classic that sits on every official "Best Games Of All Time" lists. Created fully destroyable terrain, skilled tactical combat AI, and once you learn the basics of the game, it draws you in without you realizing it; a feat that many games have trouble matching.
To my knowledge, aside from the X-COM Trilogy, and Silent Storm and Silent Storm Sentinels, fully destroyable terrain is something no other squad tactical has been able to match, including almost every other game of any genre as well.